Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways.

Miller JA, Horvath S, Geschwind DH
Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12698-703. PMID: 20616000. Abstract
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Comments

Submitted by YuHong Fu, PhD on

This work identifies convergent and divergent pathways in mouse and human, and provides a systematic framework that will be useful for understanding the applicability of mouse models for human brain disorders.

Submitted by Wei Chen on

The authors find that convergent and divergent pathways in mouse and human, which provides a systematic framework that will be useful for understanding the applicability of mouse models for human brain disorders.