Response to: Perucho J et al (2010) J Alzheimers Dis 19, 1245-1259.

1 May 2010

We note that Perucho et al. [1] cite (reference number 28) a 2007 publication by Pravat K Mandal [2], and we wish to point out to the authors and your readers that the Biochemistry paper in question was retracted later that same year [3], as was another article by Mandal [4], because “the anesthetic concentration of our paper[s] was misrepresented”. Those papers should therefore not be cited as evidence.

We also note in passing that the reference to Mandal’s retracted paper was incomplete (missing two authors [2]) and another citation of the work of Mandal and Fodale (reference 7 in Perucho et al) is also misreferenced. The citation to the latter should be 2009, not 2006, and the title of both the article and journal are incorrect [5].

Dr John Loadsman, MB, BS, PhD, FANZCA
Conjoint Senior Lecturer and Staff Specialist
Department of Anaesthetics
University of Sydney and Royal Prince Alfred Hospital
Camperdown 2050
Australia

Dr Francois Stapelberg, MBChB, FANZCA
Specialist Anaesthetist
Department of Anaesthesia
Senior Clinical Lecturer
University of Auckland and Middlemore Hospital
Auckland 1640
New Zealand

References:
[1] Perucho J, Rubio I, Casarejos MJ, Gomez A, Rodriguez-Navarro JA, Solano RM, de Yebenes JG, Mena MA (2010) Anesthesia with isoflurane increases amyloid pathology in mice models of Alzheimer’s disease. J Alzheimers Dis 19, 1247-1259.
[2] Mandal PK, Williams JP, Mandal R (2007) Molecular understanding of Abeta peptide interaction with isoflurane, propofol, and thiopental: NMR spectroscopic study. Biochemistry 46, 762-771.
[3] Mandal PK (2007) Molecular understanding of Abeta peptide interaction with isoflurane, propofol, and thiopental: NMR spectroscopic study. [Retraction of Mandal PK, Williams JP, Mandal R. Biochemistry. 2007 Jan 23;46(3):762-71; PMID: 17223697] Biochemistry 46, 12887.
[4] Mandal PK. Pettegrew JW (2008) Alzheimer's disease: halothane induces Abeta peptide to oligomeric form - solution NMR studies. [Retraction of Mandal PK, Pettegrew JW, McKeag DW, Mandal R. Neurochem Res. 2006 Jul;31(7):883-90; PMID: 16807784] Neurochem Res 33, 220.