The latent dementia phenotype δ is associated with cerebrospinal fluid biomarkers of Alzheimer’s disease and predicts conversion to dementia in subjects with mild cognitive impairment

Manuscript Number: 

15-0257R2

Author(s): 
Lutz Frölich, Hermann-Josef Gertz, Harald Hampel, Fritz Henn, Isabella Heuser, Michael Hüll, Holger Jahn, Frank Jessen, Luca Kleineidam, Alexander Koppara, Johannes Kornhuber, Alexander Kurz, Christian Luckhaus, Wolfgang Maier, Johannes Pantel, Oliver Peters, Friedel M. Reischies, Otto Rienhoff, Eckart Ruther, Klaus Schmidtke, Johannes Schroder, Stefanie Schulz, Michael Wagner, Jens Wiltfang, Steffen Wolfsgruber

Disclosures

Lutz Frölich

  • Consulting Fees:
    paid advisory boards: Eisai, Eli Lilly, GE Health Care, Janssen-Cilag, Lundbeck, Merz Pharma, Novartis, Pfizer, Schering-Plough, Consultancy fee:AstraZeneca, Merz Pharma, Myriad, Neurochem, Novartis, Pfizer, Schering-Plough
    Lecture Fees:
    satellite symposium: Pfizer, Novartis
    Patents/Royalties
    expert witness: Apotex Inc.
    Grants
    • Agency: 
      Novartis Germany
      Dates: 
      2015
    • Agency: 
      Piramal Germany
      Dates: 
      2015
    • Agency: 
      Pfizer
      Dates: 
      2008

Hermann-Josef Gertz

  • Nothing to Disclose

Harald Hampel

  • Consulting Fees:
    Scientific advisory board and/or consultancy functions: Eli Lilly and company, Biogen, Avid, GE Healthcare, Roche, Cytox, Jung Diagnostics
    Lecture Fees:
    Honoraria and/or logistical support of scientific lectures: Pfizer, Novartis, Biogen, Roche, Cytox, Eli Lilly and company
    Patents/Royalties
    Patent submissions (partly pending) as scientific co-inventor (institutions: Thermo Scientific B•R•A•H•M•S Biomarkers, Applied NeuroSolutions, DiaMed, The Genetics), no royalties, no other activities.

Fritz Henn

  • Nothing to Disclose

Isabella Heuser

  • Nothing to Disclose

Michael Hüll

  • Consulting Fees:
    Advisory Board Roche 1500€
    Grants
    • Agency: 
      Schwabe GmbH
      Dates: 
      2013-2015
    • Agency: 
      Pfizer
      Dates: 
      2009-2015
    • Agency: 
      AbbVie
      Dates: 
      2012-2014

Holger Jahn

  • Nothing to Disclose

Frank Jessen

  • Consulting Fees:
    novartis, Nutricia, Schwabe, Lilly

Luca Kleineidam

  • Nothing to Disclose

Alexander Koppara

  • Nothing to Disclose

Johannes Kornhuber

  • Patents/Royalties
    Methods of differentially diagnosing dementias (EP 2095128B1) New formulations for diagnosis of Alzheimer's disease Diagnosis of Alzheimer's disease (EP 1 620 733 A1) Immunoglobulin-bound Ab-peptides and immunoglobulins-binding Ab-peptides in diagnosis and therapy of Alzheimer's dementia (WO2007/082750 A1) Large Aß-peptide binding particles (LAPS) in diagnosis and therapy of Alzheimer's dementia (EP 1 811 304 A1)

Alexander Kurz

  • Nothing to Disclose

Christian Luckhaus

  • Nothing to Disclose

Wolfgang Maier

  • Consulting Fees:
    Lundbeck, Lilly

Johannes Pantel

  • Consulting Fees:
    Fa. Willmar Schwabe GmbH & Co KG, Karlsruhe, Germany Fa. Vitaphone GmbH , Mannheim , Germany

Oliver Peters

  • Consulting Fees:
    Lilly, Novartis
    Grants
    • Agency: 
      Lilly
      Dates: 
      2010-2015
    • Agency: 
      Trx-Pharmaceuticals
      Dates: 
      2013-2015
    • Agency: 
      Roche
      Dates: 
      2010-2015
    • Agency: 
      Lundbeck
      Dates: 
      2014-2015

Friedel M. Reischies

  • Nothing to Disclose

Otto Rienhoff

  • Nothing to Disclose

Eckart Ruther

  • Nothing to Disclose

Klaus Schmidtke

  • Nothing to Disclose

Johannes Schroder

  • Nothing to Disclose

Stefanie Schulz

  • Nothing to Disclose

Michael Wagner

  • Nothing to Disclose

Jens Wiltfang

  • Lecture Fees:
    Janssen, lecture
    Patents/Royalties
    patent no.: EP1270592B1; patent no.: US 6,849,416 B2; patent no.: EP2095128B1
    Grants
    • Agency: 
      Immungenetics AG
      Dates: 
      2015
    • Agency: 
      Fa. Hoffmann – La Roche Ltd
      Dates: 
      2015
    • Agency: 
      Probiodrug AG
      Dates: 
      2015

Steffen Wolfsgruber

  • Nothing to Disclose