A common variant of IL-6R is associated with elevated IL-6 pathway activity in Alzheimer’s disease brains

Manuscript Number: 

16-0524R2

Author(s): 
Timothy W. Behrens, Tushar R. Bhangale, Carlos Cruchaga, Lindsay A. Farrer, Alison M. Goate, Robert R. Graham, Patrick C.G. Haddick, Jonathan L. Haines, David V. Hansen, Joshua S. Kaminker, John S.K. Kauwe, Jessica L. Larson, Jennie R. Lill, Margaret A. Pericak-Vance, Qui T. Phung, Nisha Rathore, Gerard D. Schellenberg, Karpagam Srinivasan, Ryan J. Watts, Marcel van der Brug

Disclosures

Timothy W. Behrens

  • Equity:
    Roche stock and stock options
    Sponsors:
    Roche/Genentech

Tushar R. Bhangale

  • Sponsors:
    I am an employee at Genentech Inc

Carlos Cruchaga

  • Nothing to Disclose

Lindsay A. Farrer

  • Nothing to Disclose

Alison M. Goate

  • Consulting Fees:
    Denali Therapeutics SAB - $10,000pa AbbVie - $1500
    Lecture Fees:
    Eli Lilly - travel Biogen - travel plus $500 honorarium
    Patents/Royalties
    Patent on tau mutations receive royalties from Taconic Industries Patent on TDP43 mutations receive royalties from Athena Diagnostics

Robert R. Graham

  • Equity:
    Genentech, Inc.
    Sponsors:
    Full time Employee of Genentech, Inc

Patrick C.G. Haddick

  • Sponsors:
    Full time employer at Genentech during this study

Jonathan L. Haines

  • Nothing to Disclose

David V. Hansen

  • Equity:
    Roche long-term incentive awards— modest holdings
    Sponsors:
    I am a full-time researcher in the Neuroscience department at Genentech.

Joshua S. Kaminker

  • Equity:
    ROG.VX
    Sponsors:
    Senior Scientist at Genentech

John S.K. Kauwe

  • Nothing to Disclose

Jessica L. Larson

  • Equity:
    I currently have options at my employer, Asuragen, Inc.
    Sponsors:
    During the time the study was conducted, I was an employee at Genentech. I am currently an employee at Asuragen.

Jennie R. Lill

  • Nothing to Disclose

Margaret A. Pericak-Vance

  • Nothing to Disclose

Qui T. Phung

  • Sponsors:
    I work for Genentech and perform basic research using analytical tools such mass spectrometry.

Nisha Rathore

  • Equity:
    Employee stock option from Roche.
    Sponsors:
    I am a Genentech Inc, employee. Genentech Inc (A member of the Roche group) 1 DNA way, South San francisco 94010

Gerard D. Schellenberg

  • Nothing to Disclose

Karpagam Srinivasan

  • Equity:
    I own Roche Stocks.
    Sponsors:
    I am an employee of Genentech/Roche

Marcel van der Brug

  • Equity:
    Genentech employee
    Sponsors:
    Employee of Genentech

Ryan J. Watts

  • Nothing to Disclose