Concentration-dependent activity of hydromethylthionine on clinical decline and brain atrophy in a randomized controlled trial in behavioral variant frontotemporal dementia

Manuscript Number: 

19-1173R1

Author(s): 
Thomas C. Baddeley, Peter Bentham, Luc Bracoud, Harish Ganesan, Serge Gauthier, Jeffrey Hammel, Jiri H. Hardlund, Charles R. Harrington, Jianping Jia, Christopher Kipps, Karin A. Kook, Hans J. Moebius, Alison Murray, Gernot Riedel, Christopher M. Rubino, Björn O. Schelter, Helen Shiells, Roger T. Staff, John M.D. Storey, Vesna Vuksanovic, Claude M. Wischik, Damon J. Wischik

Disclosures

Thomas C. Baddeley

  • Equity:
    A small number of shares in TauRx
    Sponsors:
    Salary, Head of Analytical Chemistry and DMPK for TauRx
    Patents/Royalties
    Named author on several patents with TauRx

Peter Bentham

  • Sponsors:
    Consultant Clinical Advisor

Luc Bracoud

  • Nothing to Disclose

Harish Ganesan

  • Nothing to Disclose

Serge Gauthier

  • Consulting Fees:
    TauRx, BI, Biogen, scientific advisory boards

Jeffrey Hammel

  • Nothing to Disclose

Jiri H. Hardlund

  • Sponsors:
    I was employed by TauRx Therapeutics Ltd.during the study reported.

Charles R. Harrington

  • Equity:
    Shares in TauRx Therapeutics Ltd.
    Sponsors:
    Employed as Chief Scientific Officer of TauRx Therapeutics Ltd.
    Patents/Royalties
    I am a named inventor on several patents in the field of neurodegenerative diseases and therapeutic approaches. Patents owned by WisTa Laboratories Ltd., an affiliate of TauRx Therapeutics Ltd.
    Grants
    • Agency: 
      TauRx Therapeutics Ltd
      Dates: 
      Since 2002

Jianping Jia

  • Nothing to Disclose

Christopher Kipps

  • Nothing to Disclose

Karin A. Kook

  • Consulting Fees:
    Consultant to numerous pharmaceutical companies, including TauRx, and a paid member of one Corporate Advisory Board.

Hans J. Moebius

  • Patents/Royalties
    Co-inventor on 2 patents relating to therapy of BPSD in Alzheimer's Disease. No royalties. Acting / CMO for two biotech start-ups, none related to treatment of FTD.

Alison Murray

  • Patents/Royalties
    Wischik, C. M., Harbaran, D. V., Riedel, G., Deiana, S., Goatman, E. A., Wischik, D. J., Murray, A. D. & Staff, R. T. Phenothiazine compounds for treating mild cognitive impairment. 15 Dec 2015 17 Jun 2008 19 Jun 200760/945006. Patent
    Grants
    • Agency: 
      Canon Medical Research Europe and Philips Healthcare
      Dates: 
      01/02/2019-31/01/2022

Gernot Riedel

  • Nothing to Disclose

Christopher M. Rubino

  • Consulting Fees:
    ICPD received consulting fees from TauRx to perform the PK-PD analyses described in this manuscript.

Björn O. Schelter

  • Consulting Fees:
    I am paid consultant and subject matter expert for TauRx, the sponsor of the study, as well as GentingTauRxDiagnostics. I consult in various aspects of data analytics and biostatistics.
    Patents/Royalties
    I am co-inventor on various patents related to my TauRx/GentingTauRxDiagnostics role.
    Grants
    • Agency: 
      WistaLab
      Dates: 
      01 Jan 2019 - 31 Dec 2021

Helen Shiells

  • Sponsors:
    Employee of TauRx Therapeutics Ltd.

Roger T. Staff

  • Consulting Fees:
    I have received some consulting income from TauRx Ltd

John M.D. Storey

  • Equity:
    Hold stock in TauRx Therapeutics Ltd.
    Sponsors:
    Chief Technical Officer for TauRx Therapeutics Ltd.
    Patents/Royalties
    Patents on chemical synthesis of compounds as therapeutic agents for treatment of Alzheimer's disease and other neurodegenerative disorders. All rights assigned to WisTa Laboratories, an affiliate of TauRx.
    Grants
    • Agency: 
      TauRx Therapeutics Ltd
      Dates: 
      Since 2002

Vesna Vuksanovic

  • Nothing to Disclose

Claude M. Wischik

  • Equity:
    Equity in TauRx Therapeutics Ltd.
    Sponsors:
    Executive Chair, TauRx Therapeutics Ltd.
    Patents/Royalties
    Patents related to the treatment of Alzheimer's disease and related disorders.
    Grants
    • Agency: 
      TauRx Therapeutics Ltd
      Dates: 
      Since 2002

Damon J. Wischik

  • Patents/Royalties
    PCT international applications: WO08/155533, WO09/044127, WO09/060191
    Grants
    • Agency: 
      Toyota Mobility Foundation
      Dates: 
      2018--2021