Title | Medial Temporal Atrophy in Posterior Cortical Atrophy and Its Relationship to the Cingulate Island Sign. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Josephs, KA, Pham, NTrang Thu, Graff-Radford, J, Machulda, MM, Lowe, VJ, Whitwell, JL |
Journal | J Alzheimers Dis |
Volume | 86 |
Issue | 1 |
Pagination | 491-498 |
Date Published | 2022 |
ISSN | 1875-8908 |
Keywords | Alzheimer Disease, Atrophy, Fluorodeoxyglucose F18, Humans, Lewy Body Disease, Magnetic Resonance Imaging, Positron-Emission Tomography |
Abstract | BACKGROUND: It has been hypothesized that medial temporal sparing may be related to preserved posterior cingulate metabolism and the cingulate island sign (CIS) on [18F]fluorodeoxyglucose (FDG) PET in posterior cortical atrophy (PCA). OBJECTIVE: To assess the severity of medial temporal atrophy in PCA and determine whether the presence of a CIS is related to medial temporal sparing. METHODS: Fifty-five PCA patients underwent MRI and FDG-PET. The degree and symmetry of medial temporal atrophy on MRI was visually assessed using a five-point scale for both hemispheres. Visual assessments of FDG-PET coded the presence/absence of a CIS and whether the CIS was symmetric or asymmetric. Hippocampal volumes and a quantitative CIS were also measured. RESULTS: Medial temporal atrophy was most commonly mild or moderate, was symmetric in 55% of patients, and when asymmetric was most commonly worse on the right (76%). Older age and worse memory performance were associated with greater medial temporal atrophy. The CIS was observed in 44% of the PCA patients and was asymmetric in 50% of these. The patients with a CIS showed greater medial temporal asymmetry, but did not show lower medial temporal atrophy scores, compared to those without a CIS. Hippocampal volumes were not associated with quantitative CIS. CONCLUSION: Mild medial temporal atrophy is a common finding in PCA and is associated with memory impairment. However, medial temporal sparing was not related to the presence of a CIS in PCA. |
DOI | 10.3233/JAD-215263 |
Alternate Journal | J Alzheimers Dis |
PubMed ID | 35068459 |
PubMed Central ID | PMC8918051 |
Grant List | R01 AG050603 / AG / NIA NIH HHS / United States |