LATEST JAD EDITORS’ BLOG Music Experiences for Persons with Alzheimer’s Disease by Amy Clements-Cortés, PhD
The 2017 Alzheimer Award goes to Shi-Jiang Li for "Staging Alzheimer's Disease Risk by Sequencing Brain Function and Structure, Cerebrospinal Fluid, and Cognition Biomarkers". For more information, click here or go to www.j-alz.com/award.
The Journal of Alzheimer's Disease
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Double anti-tau (AT8, green) and anti-Aβx-40 (red) immunofluorescent staining. Labeling do not co-localize in the neuronal profiles (merged in C) suggesting two separate neurodegenerating populations in AD brains. From Lacosta et al., JAD58(3).
Endogenous intracellular tau in primary mouse neurons aggregates after the cells are exposed to extracellular oligomers, but neither monomers nor filaments made from human 2N4R tau. From Swanson et al., JAD58(3).
Immunofluorescence assay showed that the expression of PSD-93 (green) was decreased in the hippocampus of 6-month-old AD mice, but decreased PSD-93 was not detected in the cortex. From Yu et al., JAD59(3).
Astroglia and microglia colocalization with Aβ/AβPP-containing neurons. Double immunofluorescence detection of cortical astrocytes (anti-GFAP and 6E10 mAbs, left), or cortical microglia (Iba1 and 6E10, right), in 3xTg-AD mice. Scale bars, 10 µm. Esquerda-Canals et al., JAD59(3).
Genetic deletion of TNF-α results in reduced Thioflavine S-positive amyloid plaque load and decreased plaque-associated microglial (Iba1) and astrocytic (GFAP) activation in the cortex and the subiculum of the hippocampus of 4-month-old 5XFAD mice. From Paouri et al., JAD60(1).
Immunofluorescence stainings of control cultures and cultures exposed to Aβ42 protofibrils show a vesicular expression pattern of Apolipoprotein E (apoE) (red) close to the plasma membrane of astrocytes (green) following Aβ treatment. From Nikitidou et al., JAD60(1).