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LATEST JAD EDITORS’ BLOG
Lots of evidence for, but where is the evidence against?
The case for a viral role in Alzheimer's disease
by Ruth Itzhaki, PhD

The 2016 Alzheimer Award goes to Mark Bondi for "Subtle Cognitive Decline and Biomarker Staging in Preclinical Alzheimer's Disease." For more information, click here or go to http://www.j-alz.com/award.

The Journal of Alzheimer's Disease

is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease.

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We applied bibliometric analytics to identify 300 highly cited papers relevant to AD research, published in the last 5 years. Members voted for their top 10 most influential papers. See the results!

The Alzheimer’s Funding Analyzer (AFA) showcases funding distribution from 42 countries and allows the end-user to conduct line-of-investigation queries to look for funding trends.

Intraneural accumulation of amylin (green) increases synthesis of IL-1β (red) in brains of patients with Alzheimer’s disease and Type-2 diabetes (AD-T2D). Scale bars, 20 μm. From Verma et al., JAD53(1)

Physical exercise increases hippocampal neurogenesis in the TgCRND8 mouse model of amyloidosis. The merged images show colocalization of BrdU/NeuN markers (arrow) and BrdU/GFAP markers (arrowhead). Scale bar: 50 μm. From Maliszewska-Cyna et al., JAD53(1).

In the delayed-match-to-sample task, mild cognitive impairment patients (MCI) showed reduced repetition-driven suppression in the occipital brain regions relative to normal controls (NC). Activation is in red and deactivation is in blue. From Yu et al., JAD53(2).

Changes in Claudin-5 expression (green) after treatment with selected FDA approved drugs demonstrate their repurposing potential to rectify compromised blood-brain barrier integrity in Alzheimer's disease and CAA (scale bar = 50 µm). From Qosa et al., JAD53(4).

Cell-type composition of primary mixed cultures (MIX-S). Approximately 56% and 44% of the MIX-S were made up of neurons identified by NeuN and Tuj1 (red) and astrocytes identified by GFAP (green), respectively; Hoechst 33342 was used to mark nuclei (blue). From Li et al., JAD54(1).

Effect of paired helical filament (PHF) in altering dynein localization (marked in red/with arrows), near the pericentrin-positive centrosome (marked in magenta). PHF promotes tau aggresomes in GFP-tagged human tau expressing human embryonic kidney cells. From Varghese et al., JAD54(2).

Oleuropein aglycone (OLE), the main polyphenol found in the olive oil, inhibits poly(ADP-ribose) (PAR) polymers formation in the cortex of TgCRND8 mice (Tg OLE). Double immunofluorescence with NeuN (red) and PAR (green) antibody plus DAPI (blue). PAR immunoreactivity is found mainly within neuronal nuclei, as shown in the merge panels. From Luccarini et al., JAD54(2).

Uptake of DiI-acetylated low density lipoprotein by adult human microglia in low (left) and high (right) passage cultures. From Guo et al., JAD54(3).

Also of interest:

 

Journal of Huntington's Disease
Journal of Neuromuscular Diseases
Journal of Parkinson's Disease

 

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Welcome to Journal of Alzheimer's Disease

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Journal Ranking

The Journal of Alzheimer's Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease.

JAD has an Impact Factor of 3.920 (2016 Journal Citation Reports), an h-index of 77 (Web of Science), an h-index of 85 (SCImago Journal Rank indicator), an h5-index of 67 (Google Scholar), and an h5-median of 83 (Google Scholar).

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