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Running and Walking May Lower Alzheimer's Disease Risk

Paul T. Williams, PhD

An estimated 5 million Americans aged 65 and older have Alzheimer’s disease. As drug companies struggle to find a cure, new research from the National Runners’ and Walkers’ Health Study suggests that exercise earlier in life may substantially reduce Alzheimer’s disease mortality.

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New Data Suggest Treatment Effect on Cognition Leads to the Treatment Effect on Function in Patients with Mild Alzheimer’s Disease

Eli Lilly and Company announced results from new analyses of two Phase 3 trials evaluating the relationship between cognitive and functional treatment effects in patients with mild Alzheimer’s disease. Based on post-hoc analyses of the Phase 3 trials, the findings suggested that cognitive deficits were more apparent than functional deficits in mild Alzheimer’s disease. The apparent treatment effect on cognition based on these analyses led to the apparent treatment effect on function.

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Spinal Needles for Lumbar Puncture

We read with dismay the report ‘Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease: A Multicenter Study in Spain’ [1]. In 2005, the Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology recommended the use of atraumatic needles for lumbar puncture [2].

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