LATEST JAD EDITORS’ BLOG Alzheimer’s Disease and Spirochetosis: A Causal Relationship by Judith Miklossy, MD, PhD
9-month-old APPswe/PS1dE9 mice brains were stained with anti-CD11b (green; b) or anti-GFAP (green; d) and anti-suppressor of cytokine signaling (anti-SOCS3) (red). SOCS3 expressed on glial cells in APPswe/PS1dE9 mice mouse cortex. From Iwahara et al., JAD55(3).
Senile plaques (X-34) were surrounded by glial neuro-inflammatory reactions (GFAP- & Iba1) in the hippocampus of AβPPswe/PSEN1dE9 transgenic mice. Rivastigmine treatment blocked these inflammatory reactions. From Matsuda and Hisatsune, JAD56(1).
The Alzheimer’s Funding Analyzer (AFA) showcases funding distribution from 42 countries and allows the end-user to conduct line-of-investigation queries to look for funding trends.
Fluorescent staining of estrogen receptor alpha (ERα) in green and DAPI (blue) in hippocampal tissue of rabbits fed a high-cholesterol diet. From Brooks et al., JAD56(1).
The pTau antibody ACI-5400 staining of somata and apical dendrites of pyramidal neurons in CA1 and in cortex coincided with that of MC1 (B, green), whereas staining with a control pS396 antibody additionally stained non-tangled neurons (C, red). From Theunis et al., JAD56(2).
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Analysis for abnormal amyloid-beta metabolism. Accumulation of amyloid-beta granules is clearly seen in cultures of neurons with Down syndrome. Staining for Abeta-42 (red) and beta-III-tubulin (green); cell nuclei were counterstained with DAPI (blue). From Dashinimaev et al., JAD56(2).
Mouse primary cortical neurons were subjected to immunocytochemistry using type III β-tubulin (red) and synaptotagmin (green) as the primary antibodies. The same fields were stained with DAPI (blue) and merged. From Lin et al., JAD56(3).
Treadmill exercise markedly attenuated STZ-induced neuronal degeneration in hippocampal CA1, as evidenced by a lower level of F-Jade C staining (green). From Lu et al., JAD56(4).
Immunofluorescence images showed that, compared to control wild-type mice (WT), TauP301S promotes the accumulation of Has1 (green) in cell body of 3-week-old TauP301S Tg mice (Tau P301S). From Li et al., JAD57(2).
Magnetic resonance images of edematous amyloid-related imaging abnormalities (ARIA-E; arrows) in the brain of an aged squirrel monkey with severe cerebral amyloid angiopathy. From Heuer et al., JAD57(2).
Images of probable CAA show that regions with cerebral microbleeds or cortical superficial siderosis (seen on T2* MRI) largely overlapped with those showing increased AV1451 uptake. From Kim et al., JAD 57(3).
Resting-state functional MRI maps of the salience network (blue) and default mode network (red) in a healthy adult. Correspondence with targets of non-invasive brain stimulation (white circles) was evaluated with stereotactic markers (fish oil capsules). From Pievani et al., 57(3).