Intracerebroventricular injection of Aβ1-42 in mice causes the death of pyramidal cells (arrows) in hippocampal CA1 regions, which was reduced by simvastatin at 20mg/kg, but aggravated at 80mg/kg. Scale bar=50 μm. From Jin et al., JAD50(2).
Chronic sleep deprivation (SD) for 2 months increases senile plaque burden in adult AβPPswe/PS1ΔE9 transgenic (TG) mice. Immunofluorescence staining of 6E10 showed the senile plaques (arrowhead). From Qiu et al., JAD50(3).
Immunofluorescence staining was conducted to locate p-STAT3 (green) in cytosol and nucleus. The nuclei were stained with DAPI (blue). Pre-treatment with gx-50 significantly increased the level of p-STAT3 in nucleus. Scale bar, 50 μm. From Shi et al., JAD50(3).
Decreased fractional anisotropy in subcortical vascular cognitive impairment patients compared to healthy subjects for 14 major fiber tracts. Red bands indicate significant differences (corrected through the cluster-based statistics). From Jung and Han et al., JAD50(4).
Hippocampal CA3 region of a 3xTg-AD mouse with cells showing Amyloid-beta (green) and Arc protein (red) immunoreactivity. Note the sparse presence of the two proteins and the high degree of co-expression (asterisks). From Morin et al., JAD51(1).
Tau in stromal nerve fascicles and simple cuboidal epithelial cells in human submandibular gland. From Dugger et al., JAD51(2).
18F-Flutemetamol, 18F-AV-1451, 18F-FDG PET and t1-mprage MRI images of a patient with Presenilin-1 mutation and early onset dementia. Color bars showing SUV ranges. Taken from Smith et al., JAD 51(2).
Also of interest:
Journal of Huntington's Disease Journal of Neuromuscular Diseases Journal of Parkinson's Disease