Title | Association of COVID-19 with New-Onset Alzheimer's Disease. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Wang, L, Davis, PB, Volkow, ND, Berger, NA, Kaelber, DC, Xu, R |
Journal | J Alzheimers Dis |
Volume | 89 |
Issue | 2 |
Pagination | 411-414 |
Date Published | 2022 |
ISSN | 1875-8908 |
Keywords | Aged, Aged, 80 and over, Alzheimer Disease, COVID-19, COVID-19 Testing, Female, Humans, Retrospective Studies, SARS-CoV-2 |
Abstract | An infectious etiology of Alzheimer's disease has been postulated for decades. It remains unknown whether SARS-CoV-2 viral infection is associated with increased risk for Alzheimer's disease. In this retrospective cohort study of 6,245,282 older adults (age ≥65 years) who had medical encounters between 2/2020-5/2021, we show that people with COVID-19 were at significantly increased risk for new diagnosis of Alzheimer's disease within 360 days after the initial COVID-19 diagnosis (hazard ratio or HR:1.69, 95% CI: 1.53-1.72), especially in people age ≥85 years and in women. Our findings call for research to understand the underlying mechanisms and for continuous surveillance of long-term impacts of COVID-19 on Alzheimer's disease. |
DOI | 10.3233/JAD-220717 |
Alternate Journal | J Alzheimers Dis |
PubMed ID | 35912749 |
Grant List | R01 AA029831 / AA / NIAAA NIH HHS / United States R25 CA221718 / CA / NCI NIH HHS / United States P30 CA043703 / CA / NCI NIH HHS / United States P20 CA233216 / CA / NCI NIH HHS / United States |