Title | "Missed" Mild Cognitive Impairment: High False-Negative Error Rate Based on Conventional Diagnostic Criteria. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Edmonds, EC, Delano-Wood, L, Jak, AJ, Galasko, DR, Salmon, DP, Bondi, MW |
Corporate Authors | Alzheimer’s Disease Neuroimaging Initiative |
Journal | J Alzheimers Dis |
Volume | 52 |
Issue | 2 |
Pagination | 685-91 |
Date Published | 2016 Mar 31 |
ISSN | 1875-8908 |
Abstract | Mild cognitive impairment (MCI) is typically diagnosed using subjective complaints, screening measures, clinical judgment, and a single memory score. Our prior work has shown that this method is highly susceptible to false-positive diagnostic errors. We examined whether the criteria also lead to "false-negative" errors by diagnostically reclassifying 520 participants using novel actuarial neuropsychological criteria. Results revealed a false-negative error rate of 7.1%. Participants' neuropsychological performance, cerebrospinal fluid biomarkers, and rate of decline provided evidence that an MCI diagnosis is warranted. The impact of "missed" cases of MCI has direct relevance to clinical practice, research studies, and clinical trials of prodromal Alzheimer's disease. |
DOI | 10.3233/JAD-150986 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 27031477 |
PubMed Central ID | PMC4879874 |
Grant List | K24 AG026431 / AG / NIA NIH HHS / United States P50 AG005131 / AG / NIA NIH HHS / United States R01 AG049810 / AG / NIA NIH HHS / United States U01 AG024904 / AG / NIA NIH HHS / United States R01 AG012674 / AG / NIA NIH HHS / United States |
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