Title | Behavioral Variant Frontotemporal Dementia Performance on a Range of Saccadic Tasks. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Douglass, A, Walterfang, M, Velakoulis, D, Abel, L |
Journal | J Alzheimers Dis |
Volume | 65 |
Issue | 1 |
Pagination | 231-242 |
Date Published | 2018 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: Saccadic paradigms display changes across a number of degenerative conditions reflecting changes in the oculomotor pathway which in some conditions have been linked to disease presentation. OBJECTIVE: To examine a novel range of saccadic paradigms in behavioral variant frontotemporal dementia (bvFTD). METHODS: Prosaccade, predictive, self-paced, memory-guided, and anti-saccade tasks were examined in bvFTD patients and controls. RESULTS: A significant increase in latency for the bvFTD group was seen in all tasks. Self-paced saccades are reduced in number, memory-guided saccades display an increase in errors. Predictive saccades show an increased latency that does not remain when prosaccade latency changes are accounted for. While changes were seen across a range of paradigms, no individual task completely separated bvFTD from control participants. CONCLUSION: bvFTD patients as a group display a number of changes on saccadic testing which may reflect the frontal lobe changes seen in this condition. |
DOI | 10.3233/JAD-170797 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 30040708 |