Title | Can a Novel High-Density EEG Approach Disentangle the Differences of Visual Event Related Potential (N170), Elicited by Negative Facial Stimuli, in People with Subjective Cognitive Impairment? |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Lazarou, I, Adam, K, Georgiadis, K, Tsolaki, A, Nikolopoulos, S, Kompatsiaris, IYiannis, Tsolaki, M |
Journal | J Alzheimers Dis |
Volume | 65 |
Issue | 2 |
Pagination | 543-575 |
Date Published | 2018 |
ISSN | 1875-8908 |
Abstract | BACKGROUND: Studies on subjective cognitive impairment (SCI) and neural activation report controversial results. OBJECTIVE: To evaluate the ability to disentangle the differences of visual N170 ERP, generated by facial stimuli (Anger & Fear) as well as the cognitive deterioration of SCI, mild cognitive impairment (MCI), and Alzheimer's disease (AD) compared to healthy controls (HC). METHOD: 57 people took part in this study. Images corresponding to facial stimuli of "Anger" and "Fear" were presented to 12 HC, 14 SCI, 17 MCI and 14 AD participants. EEG data were recorded by using a HD-EEG HydroCel with 256 channels. RESULTS: Results showed that the amplitude of N170 can contribute in distinguishing the SCI group, since statistically significant differences were observed with the HC (p CONCLUSION: These preliminary findings suggest that the amplitude of N170 elicited after negative facial stimuli could be modulated by the decline related to pathological cognitive aging and can contribute in distinguishing HC from SCI, MCI, and AD. |
DOI | 10.3233/JAD-180223 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 30103320 |