Andrzej Szutowicz, Prof. MD PhD

JAD profile

Affiliation(s): 

Medical University of Gdańsk; Department of Laboratory Medicine

Areas of Interest: 

neurotoxicology, cholinergic system, brain energy metabolism

Biography & Research: 

CURRICULUM VITAE ANDRZEJ SZUTOWICZ Education 1959-1965 M.D. Medical Faculty, Medical Academy, Gdańsk, Poland 1970 Laboratory Diagnostics specialist I deg. 1966-1970 Doctoral fellowship, Department of Clinical Biochemistry, Medical Academy, Gdańsk, Poland 1970 Ph.D. Dissertation: Regulation of activity of ATP-citrate lyase 1972 NATO Advanced Study Institute: Proteins of the Nervous System, Cortona, Italy 1975 NATO Advanced Study Institute: Cell Surface Receptors, Bellagio, Italy 1977 IBRO-UNESCO Training Course: Neurochemical Methods for the Study of Putative Transmitter Metabolism in the Nervous System, Leipzig, Germany 1978 Laboratory Diagnostics specialist II deg. 1978 Doz. Degree- Dissertation: The role of ATP-citrate lyase in biosynthesis of acetylcholine and fatty acid in rat brain. 1991 Professor - scientific title Professional and Academic Appointments 1966-1970 Doctoral Fellow - Department of Clinical Biochemistry, Medical Academy, Gdańsk, Poland 1970-1971 Senior Associate - Department of Clinical Biochemistry, Medical Academy, Gdańsk, Poland 1971-1984 Assistant Professor - Department of Clinical Biochemistry, Medical Academy, Gdańsk, Poland 1974 Postdoctoral Fellow - Department of Biological Chemistry, Washington University School of Medicine St. Louis, Missouri, USA 1981-1984 Visiting Professor - Department of Biochemistry Assistant Professor - Department of Psychiatry University of Texas Health Science Center, Dallas, Texas, USA 1985-1990 Associate Professor - Department of Clinical Biochemistry, Medical Academy, Gdańsk, Poland 1991-1999 Professor - Department of Clinical Biochemistry, Medical University, Gdańsk, Poland 1999- 2012 2012 - still Head - Chair of Clinical Biochemistry, Department of Laboratory Medicine, Medical University, Gdańsk, Poland Prof. emeritus, Rector’s deputy for postgraduate training on Laboratory Diagnostics, Department of Laboratory Medicine, Medical University of Gdańsk Official duties 1970 - Head Neurochemistry Group, Department of Clinical Biochemistry, Medical University, Gdańsk, Poland 1984-1990 Director of Teaching Programme of Clinical Biochemistry for Medical Faculty Students, Department of Clinical Biochemistry, Medical University, Gdańsk, Poland 1985-2005 Head of Clinical Chemistry Laboratory Governmental Clinical Hospital No 1, Gdańsk, Poland 1987-1994 District Consultant for Laboratory Diagnostics, Elbląg District 1991-1994 Scientific Secretary of National Specialist Council for Laboratory Diagnostics 1991-1994 National Examination Commission for Specialists of Laboratory Diagnostics and Clinical Analytics 1995- Independent Bioethical Commission for Medical Research, member 1991-2001 Medical Consultant - Medical Technology Center, Warsaw 1995-still Regional Specialist for Laboratory Diagnostics 2002- still Accreditation Commission for Postgraduate Teaching Laboratories, Head. 2007 - still National Examination Commission in Laboratory Diagnostics, Gdańsk, Chairman Membership of Scientific Societies Polish Biochemical Society Polish Society of Laboratory Diagnostics (chairman of Gdańsk section 1980-1981; chairman Commission on Standardization of Enzymological Methods 1987-1990. Member of the council 1993-1995). Honorary member (2010) Polish Neuroscience Society (1990 –member, President elect 2011-2013, President 2013-2015) Neurochemistry Commission of Neurological Committee of Polish Academy of Sciences (1980-2000). Polish College of Laboratory Medicine (Chairman 1999-2001) (treasurer - 1994-1999, 2001-2003, Board Member 2006-2009, vice chairman 2010-) Institute of Experimental and Clinical Medicine Polish Academy of Sciences, Warsaw (Scientific Council member 1993 – still) Neurobiology Committee of Polish Academy of Sciences (2007 - still ) Polish Academy of Sciences (Board of Supervisors, member 2011-) European Society for Neurochemistry International Brain Research Organization International Federation for Clinical Chemistry Gdańsk Scientific Society Awards 1976 Award of Scientific Secretary of Polish Academy of Sciences 1977 First Award of Committee of Medical Sciences of Polish Academy of Sciences 1986 Third Scientific Award of the Minister of Health and Welfare 1990 First Scientific Award of the Minister of Health and Welfare 1995 Scientific Award of the Minister of Health and Welfare 1999 Scientific Award of the Minister of Health and Welfare 2000 Award Chinese Congress of Clinical Chemistry and Laboratory Medicine 2001, 2003, 2004, 2005, 2006, 2011 Scientific Awards of the Minister of Health 2005 “ Golden Neuron” Award Physiological Sciences Committee, Polish Academy of Sciences. 2008 Prime Minister Scientific Award 2011 T. Browicz Scientific Award Polish Academy of Arts and Sciences 2012 J. Hevelius Gdańsk Scientific Award 1970- 2012 26 Research Grants from Polish Academy of Sciences, Ministry of Research and Higher Education etc., 10 local Grants. Doctoral fellows trained: 12 Dozents promotions 5 Masters of Science trained - 36 Specialists in Laboratory Diagnostics or Clinical Analytics trained - 20 Gdańsk November 2015 Publications (last 10 Years) 89. Szutowicz A., Bielarczyk H., Gul S., Zielinski P., Pawełczyk T., Tomaszewicz M. Nerve growth factor and acetyl-L-carnitine evoked shifts In acetyl-CoA and cholinergic SN56 cell vulnerability to neurotoxic inputs. J. Neurosci. Res. 79, 185-192 (2005). 90. Pawełczyk T., Grdeń M., Rzepko R., Sakowicz M., Szutowicz A. Region-specific alterations of adenosine receptors expression level in kidney of diabetic rat. Am. J. Pathol. 167, 315-325 (2005). 91. Michno A., Raszeja-Specht A., Jankowska-Kulawy A., Pawełczyk T., Szutowicz A. Effect of l-carnitine on acetyl-CoA content and activity of blood platelets in healthy and diabetic persons. Clin. Chem. 51, 1673-1682 (2005). 92. Grdeń M., Podgórska A., Szutowicz A., Pawełczyk T. Altered expression of adenosine receptors In hart of diabetic rats. J. Physiol. Pharmacol. 56, 587-597 (2005) 93. Kmieć Z., Pokrywka L., Kotlarz G., Kubasik J., Szutowicz A., Myśliwski A. Effects of fasting and refeeding on serum leptin, adiponectin and free fatty acid concentrations in young and old male rats. Gerontology 51, 357-362 (2005). 26. Sakowicz M., Szutowicz A., Pawełczyk T. Differential effect of insulin and glucose level on adenosine transport in rat B lymphocytes. Int. Immunol. 17, 145-154 (2005). 27. Pawełczyk T., Sakowicz-Burkiewicz M., Kocbuch K., Szutowicz A. Differential effect of insulin and elevateda glucose level on adenosine handling in rat T lymphocytes. J. Cell. Biochem. 96, 1296-1310 (2005). 28. Bielarczyk H., Jankowska-Kulawy A., Gul S., Pawełczyk T., Szutowicz A. Phenotype dependent differential effects of interleukin-1b and amyloid-b on viability and cholinergic phenotype of T17 neuroblastoma cells. Neurochem. Int. 47, 466-473 (2005). 29. Juściński J., Raszeja-Specht A., Skibowska A., Beta S., Keita L., Roszak K., Jarmoszewicz K., Rogowski J., Szutowicz A. Rewaskularyzacja serca u chorych leczonych kwasem acetylosalicylowym. Ocena klinicznej przydatności skojarzonego zastosowania aprotyniny i desmopressyny. Kardiochir. Torakochir. Pol. 2, 43-52 30. Bielarczyk H., Gul S., Ronowska A., Bizon-Zygmańska D., Pawełczyk T., Szutowicz A., RS-a-lipoic amid protects cholinergic cells against sodium nitroprusside and amyloid-b neurotoxicity through restoration of acetyl-CoA level. J. Neurochem., 98, 1242-1251 (2006) 99. Szutowicz A., Bielarczyk H., Gul S., Ronowska A., Pawełczyk T., Jankowska-Kulawy A. Phenotype-dependent susceptibility of cholinergic neuroblastoma cells to neurotoxic inputs Metab. Brain Dis., 21, 149-161 (2006). 100.Schliebs R., Heidel K., Apelt J., Gnieździńska M., Kirazov L., Szutowicz A. Interaction of interleukin-1b with muscarinic acetylcholine receptor-mediated signaling cascade in cholinergically differentiated SH-SY5Y cells. Brain Res. 1122, 78-85 (2006) 101.Podgórska M., Kocbuch K., Grdeń M., Szutowicz A., Pawełczyk T. Reduced ability to release adenosine by diabetic rat cardiac fibroblasts due to altered expression of nucleoside transporters. J Physiol 576.1, 179-189 (2006) 102.Sakowicz-Burkiewicz M., Kocbuch K., Grdeń M., Szutowicz A., Pawełczyk T. Diabetes-induced decrease of adenosine kinase expression impairs the proliferation Potential of diabetic rat T lymphocytes. Immunology, 118, 402-412 (2006) 103.Podgórska M., Kocbuch K., Grdeń M., Szutowicz A., Pawełczyk T. Prevalance of unidirectional Na+-dependent adenosine transport and altered potential for adenosine generation in diabetic cardiac myocytes. Basic Res Cardiol 101, 214-222 (2006) 104.Michno A., Bielarczyk H., Pawełczyk T., Jankowska-Kulawy A., Klimaszewska J., Szutowicz A. Alterations of adenine nucleotide metabolism and function of blood platelets in patients with diabetes. Diabetes 56, 462-467 (2007).(IF 8.301) 105.Grdeń M., Podgórska M., Kocbuch K., Szutowicz A., Pawełczyk T. Expression of adenosine receptors in cardiac fibroblasts as a function of insulin and glucose level. Arch. Biochem. Biophys. 455, 10-17 (2006). (IF 3.022) 106.Podgórska M., Kocbuch K., Grdeń M., Szulc M., Szutowicz A., Pawełczyk T. Different signaling pathways utilized by insulin to regulate the expression of ENT2, CNT1, CNT2 nucleoside transporters in rat cardiac fibroblasts. Arch Biochem Biophys 464, 344-349 (2007). (IF-2.969) 107.Ronowska A., Gul-Hinc S., Bielarczyk H., Pawełczyk T., Szutowicz A. Effects of zinc on SN56 cholinergic neuroblastoma cells. J Neurochem, 103, 972-983 (2007).(IF-4.260) 108.Grdeń M., Podgórska M., Szutowicz A., Pawełczyk T. Diabetes-induced alterations of adenosine receptors expression level in rat liver. Exp Molec Pathol 83, 397-398 (2007). (IF-1.377) 109. Grdeń M., Podgórska M., Kocbuch K., Rzepko R., Szutowicz A., Pawełczyk T. High glucose suppresses expression of equilibrative nucleoside transporter 1 (ENT1) In rat cardiac fibroblasts through a mechanism dependent on PKC-x and MAP kinases. Cel Physiol, 151-160 (2008) (IF-3.632) 110. Ochocka A.M., Grdeń M., Sakowicz-Burkiewicz M., Szutowicz A., Pawełczyk T. Regulation of phospholipase C-d1 by ARGHAP6, a GTPase-activating protein for RhoA: Possible role for enhanced activity of phospholipase C in hypertension. J Biochem 40, 2264-2273 (2008) (IF-4.009) 111. Jankowska-Kulawy A., Gul-Hinc S., Bielarczyk H., Suszkiw J. B., Pawełczyk T., Dyś A., Szutowicz A. Effects of lead on cholinergic SN56 neuroblastoma cells. Acta Neurobiol Exp, 68, 1-10 (2008) (IF-1.06) 112. Strzelczyk B., Szulc A., Rzepko R., Kitowska A., Skokowski J., Szutowicz A., Pawełczyk T. Identification of high-risk stage II colorectal tumors by combined analysis of the NDRG1 gene expression and the depth of tumor invasion. Ann Surgic Oncol, 16, 1287-1294 (2009) 113. Suwalsky M., Novoa V., Villena F., Sotomayor C. P., Aguilar L. F., Ronowska A., Szutowicz A. Structural effects of Zn2+ on cell membranes and molecular models. J Inorgan Biochem, 103, 797-804 (2009) 114. Wróblewska M., Kortas-Stempak B., Szutowicz A., Badzio T. Phosppholipids mediated conversion of HDLs generates specific apoA-II pre-b mobility particles. J Lipid Res, 50, 667-675 (2009) 115.Kocbuch K., Sakowicz-Burkiewicz M., Grdeń M., Szutowicz A., Pawełczyk T. Effect of insulin and glucose on adenosine metabolizing enzymem in human B lymphocytes. Acta Biochim. Polon. 56, 439-446 (2009) (IF 1.262) 116. Sakowicz-Burkiewicz M., Kocbuch K., Grdeń M., Szutowicz A., Pawełczyk T. Protein kinase C mediated high glucose effect on adenosine receptors expression In rat B lymphocytes. J. Physiol. Pharmacol. 60, 145-153 (2009) 117. Ronowska A., Dyś A., Jankowska-Kulawy A., Klimaszewska-Łata J., Bielarczyk H., Romianowski P., Pawełczyk T., Szutowicz A. Short-term effects of zinc on acetylocholine metabolism and viability of SN56 cholinergic neuroblastoma cells. Neurochem. Internatl. 56, 143-151 (2010) . 118. Wróblewska M, Szutowicz A. Apo A-II participates in HDL-liposome interaction by the formation of new pre-b mobility particles and the modification of liposomes. Biochim. Biophys. Acta. Mol. Cell Biol. Lipids 1801, 1323-1329 (2010) . 119. Jankowska-Kulawy A., Bielarczyk H., Pawełczyk T., Wróblewska M., Szutowicz A. Acetyl-CoA and acetylcholine metabolizm in nerce terminal compartment of thiamine deficient rat brain. J. Neurochem. 115, 333-342 (2010) . 120. Sakowicz-Burkiewicz M., Kocbuch K., Garden M., Szutowicz A., Pawełczyk T. Regulation of ademosine receptors expression in rat B lymphocytes by insulin. J. Cell, Biochem. 109, 396-405 (2010) . 121. Sakowicz-Burkiewicz M., Kocbuch K., Grdeń M., Szutowicz A., Pawełczyk T. Adenosine 5’-triphosphate is the predominant source of peripheral adenosine in human B Lymphobalsts. J. Physiol. Pharmacol. 61, 491-499 (2010) 122. Jankowska-Kulawy A., Bielarczyk H., Pawełczyk T., Wróblewska M., Szutowicz A. Acetyl-CoA deficit in brain mitochondria in experimental thiamine deficiency encephalopathy. Neurochem. Int. 57, 851-856 (2010) (IF 3.541). 123. Bizon-Zygmańska D., Jankowska-Kulawy A., Bielarczyk H., Pawełczyk T., Ronowska A., Marszałł M., Szutowicz A. Acetyl-CoA metabolizm In amprolium-evoked thiamine pyrophosphate deficits in cholinergic SN56 neuroblastoma cells. Neurochem. Int. 59, 208- 216 (2011) 124.Suwalsky M., Fierro P., Villena F., Aguilar L.F., Sotomayor C.P., Jemioła-Rzemińska M., Strzałka K., Gul-Hinc S., Szutowicz A. Human erythrocytes and neuroblastoma cells are in vitro affected by sodium orthovanadate. Biochim. Biophys. Acta 1818, 2260-2270 (2012) 125. Sakowicz-Burkiewicz M., Kocbuch K., Grdeń M., Maciejewska I., Szutowicz A., Pawełczyk T. Impact of adenosine receptors on immunoglobin production by human peripheral blond lymphocytes. J. Physiol. Pharmacol. (2012) 63, 661-668. 126. Sakowicz-Burkiewicz M., Kocbuch K., Grdeń M., Maciejewska I., Szutowicz A., Pawełczyk T. High glucose concentration impairs ATP outflow and immunoglobulin production by human peripheral B lymphocytes: involvement of P2X7 receptor. Immunobiology (2013) 218, 591-601. 127. Sakowicz-Burkiewicz M., Kitowska A. Grdeń M., Maciejewska I., Szutowicz A., Pawełczyk T. Differential effect of adenosine on growth of human colon cancer HCT116 and HT-29 cell lines. Arch. Biochem Biophys.533 47-54 (2013) 128. Sakowicz-Burkiewicz M., Grden M, Maciejewska I., Szutowicz A., Pawełczyk T. High glucose impairs ATP formation on the surface of human peripheral blood B lymphocytes. Int. J. Biochem. Cell Biol. 45, 1246-1254 (2013) 129. Suwalsky M., Fierro P., Villena F., Gallardo M.J., Jemioła-Rzemińska M., Strzałka K., Gul-Hinc S., Ronowska A., Zysk M., Szutowicz A. Effects of sodium metavanadate on in vitro neuroblastoma and red blood cells. Arch. Biochem. Biophys. 535, 248-256 (2013) 130. Klimaszewska-Łata J., Gul-Hinc S., Bielarczyk H., Ronowska A., Zyśk M., Grużewska K., Pawełczyk T., Szutowicz A. Differential effects of lipopolysaccharide on energy metabolism in murine microglial N9 and cholinergic SN56 neuronal cells J. Neurochem. 133, 284-297 (2015) Reviews & Book Chapters Szutowicz A., Bielarczyk H., Jankowska-Kulawy A., Pawełczyk T., Ronowska A. Acetyl- CoA the key factor for survival or death of cholinergic neurons in course of neurodegenerative diseases. Neurochem. Res. 38, 1523-1542 (2013). 17.Szutowicz A., Bielarczyk H., Ronowska A., Gul-Hinc S., Klimaszewska-Łata J., Dyś A., Zyśk M., and Pawełczyk T. Intracellular redistribution of acetyl-CoA, the pivotal point in differential susceptibility of cholinergic neurons and glial cells to neuro- degenerative signals. Biochem. Soc. Trans. 41, 1101-1106 (2014) 18. Szutowicz A., Bielarczyk H., Jankowska-KulawyA., RonowskaA., Pawełczyk T. Potential properties of retinoic acid as therapeutic option in Alzheimer’s disease: Cholinergic restoration. Exp. Rev. Neurother. 15, 239-249 (2015) Szutowicz A., Jankowska-Kulawy A., Bielarczyk H. Disurbances in acetyl-CoA metabolism: A key factor in preclinical and overt thiamine deficiency encephalopathy. In Food and Nutritional Components in Focus No 4, B Vitamins and Folate Chemistry, Analysis, Function and Effects (Brady V.P. ed) Royal Society of Chemistry str. 553-571 (2013). 12. Jankowska-Kulawy A., Ronowska A., Szutowicz A., Energy-dependent mechanisms of cholinergic neurodegeneration. In Neurochemistry (Heinbockel T. ed.) Intech str 375- 404 (2014) 13. Bielarczyk H., Szutowicz A., Thomson E.J. Neurochemistry. In Medical Biochemistry (Baynes J.W., Dominiczak M.H. eds.) Sunders Elsevier str. 564-572 (2014).