Biography & Research:
The pursuit of effective treatment strategies for neurodegenerative disorders afflicting Veterans has been my main focus for many years. Neurons are particularly sensitive to insults and we have identified underlying mechanisms responsible for this unusual susceptibility in human samples and model systems. Neuron loss involves a complex interaction between different cell types present in the brain and spinal cord. Through discovery of regulatory mechanisms important to the health of neurons, we have identified factors that are targeted in our development of therapeutic strategies to combat neurodegeneration.