14 January 2015
We read with interest the article by Hernández et al. on the TMEM106B genetic variant rs1990622 that modifies the risk for frontotemporal dementia (FTD) . Although the authors were underpowered to detect a significant association with FTD risk in their case-control study (n/N=146/381), the effect was concordant with the expected direction and slightly decreased in p-value under a recessive model. Similarly, meta-analysis of published data was more significant assuming a recessive effect for the rs1990622 CC genotype.
30 November 2014
We read with dismay the report ‘Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease: A Multicenter Study in Spain’ . In 2005, the Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology recommended the use of atraumatic needles for lumbar puncture . This was based on only one study in the neurology literature, but overwhelming evidence in the anesthesiology literature . We find it astounding that in 2014, cutting edge-tipped spinal needles are still being used for this purpose.
13 November 2014
We are writing this letter in reference to the recent paper by Gharbiya and coworkers titled “Choroidal thinning as a new finding in Alzheimer's disease: evidence from enhanced depth imaging spectral domain optical coherence tomography” .
13 August 2014
The lack of correlation between the incidence of Lyme disease and deaths due to Alzheimer’s disease cannot reflect the lack of involvement of Borrelia burgdorferi in Alzheimer’s dementia
I am writing this letter in reference to the recent paper by Danton and Catalano . I have read with interest their investigation based on the anticipation that “If the biological agent Borrelia burgdorferi that causes LD (Lyme disease) also causes AD (Alzheimer’s disease), then areas with the highest levels of LD should have significantly higher numbers of deaths due to AD compared to low LD areas.”
20 July 2014
I am writing with reference to the recent paper by Coskuner and Murray . I am sorry but I find it very hard to believe that these authors were not aware of our previous research in the field of ATP and amyloid-β (Aβ) [2-4]. In this research, we show unequivocally that ATP, ATP + Mg, and ATP +Al (III) (as well as equivalent preparations using ADP and AMP) influence significantly the propensity for Aβ25-35, Aβ1-40, Aβ1-42, and amylin (IAPP) to form β sheets of amyloid under near physiological conditions.
6 May 2014
It was with great interest that we encountered the recent article by Kapila et al. . The preclinical studies from this group have contributed significantly to our understanding of the relationship between the perioperative period and cognitive loss. However, with respect to translation, we believe that a much more cautionary note is due here than presented by the article. First, the evidence in humans that the perioperative period is linked to incident dementia is weak at best. Many contradictory clinical studies exist and there is simply no consensus at this point.
16 April 2014
I have read with interest the recent report by Jin and coworkers on the putative role of SORL1 variants in sporadic Alzheimer’s disease . In their report, the authors claim a significant effect of a three-marker haplotype, but refute a second haplotype based on twenty-three case-control studies. This conclusion, it seems, is premature in view of glaring oversights.
14 April 2014
PSP-like Features without PSP Cytopathology in Three Cases of Alzheimer’s Disease/Parkinson’s DiseaseProgressive supranuclear palsy (PSP) is a progressive disabling neurodegenerative disorder manifested clinically by vertical supranucelar gaze palsy or slowing of vertical saccades, prominent postural instability, and falls. Its neuropathological substrate is 4 repeat tau deposition as neurofibrillary tangles in the basal ganglia and brainstem and tuft-shaped astrocytes.
2 February 2014
The topic of long term cognitive impairment is of concern to patients and clinicians and it is critical that it be addressed with appropriately designed studies. It is disappointing to note that despite a plethora of opinion pieces dominating the literature, there remain no prospective studies investigating dementia following surgery and anesthesia.
8 October 2013
We read with interest the article by Natunen et al.  on the role of the BACE regulating factor, GGA3, in Alzheimer’s disease (AD). In this study, as has been the case with a number of other studies [2-4], the authors utilized human postmortem brain samples to show that the temporal cortex of AD patients had decreased levels of GGA3 compared to that of age-matched controls, although the decrease was not statistically significant . In a separate study, Santosa et al.