Blood protein markers of Neocortical Amyloid-beta Burden: A candidate study using SOMAscan technology

Manuscript Number: 

15-0020R1

Author(s): 
David Baker, Chantal Bazenet, Samantha C. Burnham, Antonia Covin, Richard Dobson, Steven J. Kiddle, Simon Lovestone, Dipen P. Sangurdekar, Cristina A. Tan Hehir, Nicola Voyle, Zhanpan Zhang

Disclosures

David Baker

  • Sponsors:
    Janssen R&D

Chantal Bazenet

  • Nothing to Disclose

Samantha C. Burnham

  • Patents/Royalties
    Method for detection of a neurological disease US 20140086836 A1 ABSTRACT The present invention provides methods for predicting whether a subject will develop a disease capable of affecting cognitive function. More specifically, the present invention relates to the predictive detection of neurological diseases in a subject. The methods and systems provided enable a quantitative assessment and theoretical predictions of neocortical amyloid loading or amyloid beta levels based on the measurement of biomarkers in biological fluids that will provide an indication of whether a subject is likely to develop a neurological disease, such as Alzheimer's disease (AD).

Antonia Covin

  • Equity:
    I work for Janssen and Janssen was the Sponsor of the study.
    Sponsors:
    I work for Janssen who sponsored this study

Richard Dobson

  • Grants
    • Agency: 
      Ely Lilly
      Dates: 
      dec 14 for 2 yers

Steven J. Kiddle

  • Nothing to Disclose

Simon Lovestone

  • Lecture Fees:
    Speaker fees for the Lundbeck Neuroscience Foundation series (less than £1000)
    Patents/Royalties
    Named as inventor on patents on biomarkers pertaining to Alzheimer's disease registered by Proteome Sciences and King's College London.
    Grants
    • Agency: 
      Astra Zeneca and MRC
      Dates: 
      2012-2016
    • Agency: 
      EU and multiple commercial entities (EMIF and EPAD IMI programmes)
      Dates: 
      2012-2020

Dipen P. Sangurdekar

  • Sponsors:
    Employed at General Electric and worked as biostatistician on the project

Cristina A. Tan Hehir

  • Equity:
    Stock options with General Electric
    Sponsors:
    Employee of General Electric

Nicola Voyle

  • Nothing to Disclose

Zhanpan Zhang

  • Nothing to Disclose