Manuscript Number: 16-1242R2 Author(s): Hiroyasu Akatsu, Yoshio Hashizume, Yuichiro Ii, Hidehiro Ishikawa, Masayuki Maeda, Ko Matsuo, Atsushi Niwa, Hajime Sakuma, Akihiro Shindo, Shinichi Takase, Akira Taniguchi, Hidekazu Tomimoto