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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.

Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, et al.
Nat Genet. 2013 Dec; 45(12):1452-8. PMID: 24162737. Abstract
Top50 Topics: 
Genetics

Comments

Submitted by Amalia Bruni, MD on

This important work provides the opportunity to better characterize new candidate genes associated with Alzheimer's disease risk and to understand their exact role in AD pathophysiology., because some genes are involved in some previously suspected pathways (such as APP and tau in pathology) and others may be involved in new pathways underlying AD.