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Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its infancy.

McGeer EG, McGeer PL
J Alzheimers Dis. 2010; 19(1):355-61. PMID: 20061650. Abstract
Top50 Topics: 
Pathology, Methods

Comments

Submitted by Wei Chen on

Neuroinflammation occurred in the whole course of AD, and antiinflammatory cytokines including IL-4 and IL-10 stimulate microglia ,which may be a therapeutic potential way.

Submitted by Slavica Krantic, PhD on

The fact that aggregated amyloid-beta is not a potent activator of mouse complement system is often forgotten when studying AD-related neuroinflammation by using mouse models. This is an important difference to be kept in mind when extrapolating the murine data to human pathology.

Submitted by Judith Miklossy, MD, PhD, DSc on

This paper shows the importance to consider the inflammatory nature of brain damage in AD.