Peter Dodd, PhD
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Affiliation(s):
The Univeristy of Queensland
ORCID URL:
Areas of Interest:
molecular neuropathology, amino acids, transcriptomics, proteomics
Biography & Research:
My work on the use of autopsy tissue for studies of amino acid neurotransmission goes back 30 years. We developed and optimized protocols for good-quality mRNA and proteins that we map and precisely quantify. We make and use functional synaptosomes from stored frozen autopsy brain to analyse sub-synaptic compartments. We explore phenotype-genotype interactions genotypes in alcoholics and dementia cases, in both sexes, with and without comorbid disease. We quantify the regional distribution of receptors and their subunits. Key findings include altered expression of GABA receptors in alcoholics without comorbid disease but of glutamate receptors in cirrhotic alcoholics; and of altered expression of glutamate transporters and receptors in Alzheimer disease.
