Ulrich Eisel, PhD

JAD profile

Associate Editor

Term Expiration: 

12/31/2024

Affiliation(s): 

University of Groningen

Lab URL: 

https://myuniversity.rug.nl/infonet/medewerkers/profiles/u.l.m.eisel/

ORCID URL: 

https://orcid.org/0000-0003-4178-0384

Areas of Interest: 

Alzheimer's disease, cognitive impairment, depression, excitotoxicity, neurodegenerative diseases, neuroinflammation, neuroprotection, tumor necrosis factor

Biography & Research: 

Ulrich L. M. Eisel POSITION TITLE: Professor in Molecular Neurobiology and Neuroimmunology, Dr. rer. nat. EDUCATION/TRAINING Biology, Justus Liebig University, Giessen, Germany A. Positions, Scientific Appointments, and Honors ACADEMIC POSITIONS: Institut for Medical Virology, JLU Giessen, Germany 1985-1989 PhD summa cum laude Federal Research Institute for Viral 1989-1990 postdoctoral researcher Diseases in Animals, Tübingen, Germany National Institute of Mental Health, 1990-1993 visiting associate NIH, Bethesda, MD, USA University of Stuttgart, Germany 1993-2003 Lecturer University of Groningen, Netherlands 2003-2009 assistant professor 2009-2018 associate professor Since 2018 Full professor B. Contributions to Science (selected papers from recent years) - Dong Y, Fischer R, Naudé PJW, Maier O, Nyakas C, Duffey M, van der Zee EA, Dekens D, Douwenga W, Herrmann A, Guenzi E, Kontermann RE, Pfizenmaier K. Eisel ULM (2016) Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration Proc Natl Acad Sci, USA, 113 (43) 12304-12309. DOI/10.1073pnas.1605195113 - Blank T, .. Eisel ULM, .., Prinz M (2016) Brain endothelial specific IFNAR is key for virus-induced sickness behavior and cognitive impairment. Immunity 44(4):901-912. doi: 10.1016/j.immuni.2016.04.005. - Doortje W Dekens, Petrus J W Naudé, Sebastiaan Engelborghs, Yannick Vermeiren, Debby Van Dam, Richard C Oude Voshaar, Ulrich L M Eisel, Peter P De Deyn, (2017) Neutrophil Gelatinase-Associated Lipocalin and its Receptors in Alzheimer's Disease (AD) Brain Regions: Differential Findings in AD with and without Depression Journal of Alzheimer's disease : JAD DOI. PMID: 27716662 - Pegoretti V, Baron W, Laman JD and Eisel ULM (2018) Selective Modulation of TNF–TNFRs Signaling: Insights for Multiple Sclerosis Treatment. Front. Immunol. 9:925. doi: 10.3389/fimmu.2018.00925 - Williams SK, Fairless R, Maier O, Liermann PC, Fischer R, Eisel ULM, Kontermann R, Herrmann A, Weksler B, Romero IA, Couraud P-O, Pfizenmaier K and Diem R
(2018) Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis Scientific Reports 8:13628 | DOI:10.1038/s41598-018-31957-7 - Dekens DW, Naudé PJW, Douwenga W, Keijser JN, De Deyn PP, Eisel ULM (2018) Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load and glial activation in the J20 Alzheimer mouse model J Neuroinflammation 15(1): 330 DOI: 10.1186/s12974-018-1372- - Fischer R, Padutsch T, Bracchi-Ricard V, Murphy KL, Martinez GF, Delguercio N, Elmer N, Sendetski M, Diem R, Eisel ULM, Smeyne RJ, Kontermann RE, Pfizenmaier K, Bethea JR. (2019) Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis. Brain Behav Immun. pii: S0889-1591(19)30378-2. doi: 10.1016/j.bbi.2019.06.021. - Naudé, P. J. W., Ramakers, I. H. G. B., van der Flier, W. M., Jiskoot, L. C., Reesink, F. E., Claassen, J. A. H. R., Koek, H. L., Eisel, U. L. M. & De Deyn, P. P., (2021) Serum and cerebrospinal fluid Neutrophil gelatinase-associated lipocalin (NGAL) levels as biomarkers for the conversion from mild cognitive impairment to Alzheimer's disease dementia. Neurobiology of Aging. 107, p. 1-10. - Ortí-Casañ, N. , Zuhorn, I. S. , Naudé, P. J. W. , De Deyn, P. P. , van Schaik, P. E. M. , Wajant, H., Eisel, U. L. M. (2022) A TNF receptor 2 agonist ameliorates neuropathology and improves cognition in an Alzheimer's disease mouse model Proc Natl Acad Sci, USA 119, 37, p. e2201137119