Biography & Research:
We study the biochemistry of protein aggregation and the interconnection of this phenomenon with cell signaling pathways and intracellular communication. We aim at seeking answers to questions in this field using a combination of biochemistry, biophysics, nanotechnology and single molecule approaches. Typical questions we address in our team include:
- what is the mechanistic background of clinically identified risk factors for Alzheimer's disease?
- how do neighboring cells communicate their disease status to ultimately, in late disease stages, span the entire brain?
- how do cells of the immune system and neurons interact to give rise to neuroinflammation?
- how can we explain the molecular basis of the connection between neuroinflammation and neurodegeneration?
- how does the microbiome affect brain health?
We are embedded in the faculty of Science and Technology in the Applied Stem Cell Technologies group.