Biography & Research:
I am interested in brain function and malfunction and have a particular interest in neurodegeneration. My main focus concerns the how and why Alzheimer’s disease develops, a disease known to heavily target the medial temporal lobe memory system and in particular the entorhinal cortex. Three questions are currently the main focus of my attention: (1) Which neurons show the first sign of subtle pathological change? (2) What are the unique features of these neurons? (3) Are certain types of neurons responsible for spreading the disease to other anatomically connected regions, or do these latter become affected in an independend process?
To address these questions I use animal models and cell culture models. In addition, I work with human brain tissue such that I can relate findings made in models back to the human brain.