Charlotte Teunissen,

JAD profile

Affiliation(s): 

Amsterdam University Medical Centers - VU University

Areas of Interest: 

Alzheimer's disease, analytical validation, biomarkers, clinical validation, early diagnosis, dementia, prognosis, proteomics

Biography & Research: 

Charlotte Teunissen’s mission is to improve care of patients with neurological diseases by developing body fluid biomarkers for diagnosis, stratification, prognosis and monitoring treatment responses. She started with this line of research at the beginning of her PhD thesis. Her studies cover the entire spectrum of biomarker development, starting with biomarker identification, hypothesis based as well as by -omics methods, followed by assay development and analytical validation for the most promising biomarkers. In the next step, they perform extensive internal and external clinical validation to ultimately arrive at implementation of biomarkers in clinical practice. She has strong expertise with assay development on state of the art technologies, such as Quanterix ultrasensitive SimOA technology, and in in implementation of vitro diagnostic technologies for clinical routine lab analysis. All studies are facilitated due to Charlotte’s responsibility for a large well-characterised biobank, of >4500 paired CSF and serum samples of dementia patients (a.o. Alzheimer, Frontotemporal, Lewy Bodies) and controls with subjective complaints, that visit the memory clinic Alzheimer Center Amsterdam. To ensure the quality of our biosamples, they perform scientific studies into pre-analytical and biobanking effects, and the lab and biobank are CLIA and ISO15189 certified. Charlotte has always collaborated strongly in the field, driven by the idea that collaboration is a prerequisite for performing high quality biomarker studies. This is also visible in her lead in several collaborative networks, such as the BioMS network and in the Society for Neurochemistry and routine CSF analysis and the Alzheimer Association-Global Biomarker Standardization consortium.